Housekeeping Genes. Housekeeping genes are commonly described as "essential for cellular existence regardless of their specific function in the tissue or organism", and. For instance, there is a class of genes that is constantly being expressed, known as housekeeping genes
Examples of commonly used housekeeping genes. Download Table from www.researchgate.net
These genes have been referred to as housekeeping genes (HKGs) and are hypothesized to constitute a small set of genes required to maintain minimum basic cellular function [1]. Some genes, however, are constitutively expressed in all tissues and their expression levels are comparatively constant across different cell types
Examples of commonly used housekeeping genes. Download Table
Housekeeping genes account for majority of the active genes in the genome, and their expression is obviously vital to survival However, the relationship between these criteria has not been much discussed Introduction Housekeeping genes are often defined as being stably expressed in all cells and conditions [1], essential [2], belong to cellular maintenance pathways [1,3-6] and be conserved [7,8]
. Housekeeping genes are of broad interest for translational and basic science research Godbey, in An Introduction to Biotechnology, 2014 4.2.3.2.1.2 CpG Islands The TATA box is not the only feature that can be used to identify the location of the gene
Housekeeping Genes vs. Luxury Genes What’s the Difference?. Housekeeping genes are genes that are required for the maintenance of basal cellular functions that are essential for the existence of a cell, regardless of its specific role in the tissue or organism Author summary Housekeeping genes have often been associated with four main biological criteria-stability in expression across samples, essentiality, participation in cellular maintenance, and evolutionarily conserved